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By | February 27, 2017

Regulating Arterial Blood Pressure

One of the things that we know about hypertension is, first of all, it affects one out of every three adults. It's an epidemic in our country and it's one of the major concerns for institutes like NIH and the American Heart Association. It's primarily two disease models. Hypertension, which is higher blood pressure. And lower blood pressure, which is orthostatic intolerance. For someone who has really low blood pressure, they may have trouble standing

up with this. So with the micronography technique we're taking a tungsten microelectrode and we're inserting it into the peroneal nerve. And this right now is the gold standard for assessing sympathetic traffic. It's the only method out there where we can get direct signals of sympathetic traffic. When we're probing for a sympathetic nerve we're listening for what we call an insertion burst.

That insertion burst will give us an indication that we're actually in the nerve. Now we still have to make tiny microadjustments sometimes in order to get there because we're actually recording from multiple fibers. And what we're interested in is, individuals who are more prone to fainting have lower sympathetic tone, lower sympathetic traffic, and, or, they have a reduced ability to increase sympathetic traffic. So on one scale, one side of the spectrum we're looking at fainting and orthostatic intolerance.

On the other side of the scale, someone who has a high sympathetic traffic, outflow, and tone, often is associated with hypertension. And so we look at these patients and try to characterize their activity levels, and then we expose them to various types of intervention. So one intervention is getting more sleep, other interventions are physical activity. One that we just completed was looking at the effects of the Omega3 fatty acids, or fish oils on neurovascular control. So the longterm goal of the laboratory is to examine not only how the sympathetic nerve

system responds in individuals, but also how various types of interventions effect that responsiveness.

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